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FDA Strengthens Warning on Combining Benzos and Opioids

The FDA expanded its warnings against using opioids and benzodiazepines concomitantly. This action is based on new information on three specific opioids—buprenorphine, buprenorphine-naloxone and methadone, which are typically prescribed for the treatment of opioid use disorder—and the risk for respiratory depression when these drugs are used with benzodiazepines or other central nervous system (CNS) depressants.

According to the FDA alert, “the combined use of these drugs increases the risk of serious side effects; however, the harm caused by untreated opioid addiction usually outweighs these risks. Careful medication management by health care professionals can reduce these risks.”

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